A recent article published in Medical Express last week touts the impressive findings of a pre-clinical study on the experimental drug EBC-46 (pictured above). In the article, they claim that EBC-46 is able to effectively destroy tumors by destroying the blood vessels that supply it with oxygen and nutrients. It is important, however, to remember that the work they are reporting on is very preliminary and has yet to be shown to be safe or effective in humans. Many promising candidate drugs fail very early on in clinical trials because of an unforeseen side-effect or because the drug simply does not work as well in humans as in animal models.
Furthermore, EBC-46 may be a novel drug, but its target is nothing new. EBC-46 targets a protein called Protein Kinase C (PKC) that, when inhibited, prevents tumor cells from making proteins that help them live. PKC has been targeted by several compounds, with one, PMA getting a phase I clinical trial (safety and efficacy in a limited group of people with cancer). Unfortunately, PMA caused severe and life-threatening side effects and the trial was stopped.
Given the questionable history of PKC inhibitors, it has yet to be seen if EBC-46 will be safe to use in humans.
For the article upon which the press release was based see below:
Intra-Lesional Injection of the Novel PKC Activator EBC-46 Rapidly Ablates Tumors in Mouse Models
Edited by SITN Waves Editor Adam Brown.
Clearly those of you who think there is a big pharma ‘cabal’ have never worked in a drug company! Perhaps if there was that level of collaboration we WOULD have better treatment options. As it is, there is little sharing of knowledge due to fear of intellectual property leaks in the race to have products approved first in a given indication. You may call that ‘money grubbing’, but in this business, he who gets there second is going to eat millions of dollars in expense for research, development and clinical trials because there is no market left in label space. Also, many novel oncology treatments that are making it to market are products of smaller companies that in no way resemble BIG PHARMA. Read about the small companies that have fallen by the wayside trying to get a better drug to market. There are quite a few. While it is true that chemo and radiation are still the standard of care for many forms of cancer, there are a fair number of biologics that are providing great results with much better quality of life attributes than the non-selective chemicals/radiation we are accustomed to using.
I’m fighting leukaemia and am shocked at so much negativity and uneducated comments here. Please lets try all we can to save our lives!!!!!!😉
Everyone stands to lose someone from cancer. I just lost someone this morning. “Big Pharma” is comprised of people too. These people have family who will most certainly be affected by cancer. The only global conspiracy surrounding cancer is the conspiracy to cure it! Strides are being made but only time will tell.
yea, strides are being made alright…to put the cures further back in the vault
The efficacy of EBC-46 in humans was published 2 YEARS ago and yet it is still not available for general use to treat cancer!!! Therefore the existance of this cure had already been through in vitro and animal trials YEARS before. There is simply NO EXCUSE for cure to not be available to the public!
From http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108887
Abstract
Intra-lesional chemotherapy for treatment of cutaneous malignancies has been used for many decades, allowing higher local drug concentrations and less toxicity than systemic agents. Here we describe a novel diterpene ester, EBC-46, and provide preclinical data supporting its use as an intra-lesional treatment. A single injection of EBC-46 caused rapid inflammation and influx of blood, followed by eschar formation and rapid tumor ablation in a range of syngeneic and xenograft models. EBC-46 induced oxidative burst from purified human polymorphonuclear cells, which was prevented by the Protein Kinase C inhibitor bisindolylmaleimide-1. EBC-46 activated a more specific subset of PKC isoforms (PKC-βI, -βII, -α and -γ) compared to the structurally related phorbol 12-myristate 13-acetate (PMA). Although EBC-46 showed threefold less potency for inhibiting cell growth than PMA in vitro, it was more effective for cure of tumors in vivo. No viable tumor cells were evident four hours after injection by ex vivo culture. Pharmacokinetic profiles from treated mice indicated that EBC-46 was retained preferentially within the tumor, and resulted in significantly greater local responses (erythema, oedema) following intra-lesional injection compared with injection into normal skin. The efficacy of EBC-46 was reduced by co-injection with bisindolylmaleimide-1. Loss of vascular integrity following treatment was demonstrated by an increased permeability of endothelial cell monolayers in vitro and by CD31 immunostaining of treated tumors in vivo. Our results demonstrate that a single intra-lesional injection of EBC-46 causes PKC-dependent hemorrhagic necrosis, rapid tumor cell death and ultimate cure of solid tumors in pre-clinical models of cancer.
Holy crap you have not read the article. This study is based off mouse models and cancer cell lines. Human phase clinical trials have started only in Jan 2015, and so far they’ve only have 8 patients. Please read everything before you spew shit.
Is this the article you are referring me to? I just got a link to this conversation from the following:
https://www.google.com/amp/s/www.thesun.co.uk/news/1640943/cancer-drug-extracted-from-rainforest-berries-destroys-womans-tumour-in-days/amp/?client=safari
Very exciting if true!
Sadly this very viable CURE will be ‘studied’ and in clinical ‘trials’ for the next decade or two and then it will mysteriously disappear like so many before it.
The excuse for the lengthy trials will be to determine ‘efficacy’ and side effects meanwhile the medical/pharma industry will continue to poison, torture and surgically maim MILLIONS with chemo and radiation, while simultaneously draining their victims of their life savings, their family’s savings while their loved ones watch them wither and die a miserable death. Many on this board find this impossible to believe. They are in complete denial, unwilling to conceive the notion that profit is the medical/pharma cabal’s ONLY motivation. Any cure for cancer will immediately destroy $BILLIONS$ in revenue! Sure, there are wonderfully talented researchers and scientists that discover and refine CURES for cancer but in the end the GLOBAL medical/pharma cabal decides what the public can have access to.
You would likely be better off harvesting this berry yourself and injecting your own tumour with the juice extracted in your own kitchen then waiting for this CURE to become available. In fact I wouldn’t be surprised if EBC-46 is much more than a refined concentration of the natural molecule that is present in the raw juice with some trivial artificial modification so that it could be presented for patent as a man made substance. After all how was this berry’s curative powers discovered in the first place? It wouldn’t surprise me that they learned of the curative powers of this berry through some Aboriginal medicine man.
It is successful…a woman was interviewed that got the shot and the tumor disappeared and didn’t have to have her arm amputated. It’s natural, no side effects…smh
PMA and EBC-46 are PKC activators, and not inhibitors, as stated blog.
Rikki
Years ago my niece, who was about 22 years old, announced to all of the children, at a large Christmas Eve gathering, that there was no Santa and she did not care what their parents told them. She had some tough times growing up and this is how it manifested. Today she has 3 children under 5 years old and enjoys the excitement created and perpetuates the Santa myth.
Bob, we all have had some experiences and suffered. Someone asked, it seems in desperation, if you knew of any other potential treatments. Your response was another conspiracy statement. Please list some of these treatments, even the ones that have been squashed by corporations, with some facts, links, reputable sources, so people can learn about them, but don’t be a dick.
Rudy,
Oh stop trying to psychoanalyze me just because I am capable of thoughts beyond the sheeple’s propaganda driven capabilities.
I already have further up. Just read my comments.
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Bob
I’ve read all these posts and I can see both sides. I’m sure there are some doctors and researchers who are dedicated to finding a cure. I’m sure some of the alternative cures being suppressed are actually just money making BS. I have absolutely zero faith in Big Pharma, Big Agra, Big banks, Big Oil, etc… It is a good point that no other independent government anywhere in the world has found a cure. I’m not sure if Big Pharma fully controls every entity on Earth. Then again there’s a good chance they do. DeBeers controls the whole world’s diamond supply. The recent discovery of quadrillions of dollars in diamonds in the Russian Popigai crater didn’t lower the price by a cent. I think there’s a good chance that there is not a Cure-All since cancer is a mutation of cells trying to survive against what the body wants. I seem to remember a new approach of taking a sample of someone’s cancer and then designing a treatment specifically for that cancer. This sounds like a great idea. McAffe anti virus software has been doing this for decades. It is constantly updated to combat each new virus. I seem to remember it being named Provenge treatment which currently costs about $23,000 per month in the US. That is the key to the puzzle right there folks. Cost is what convinces me beyond any doubt that the industry is corrupt. Every new technology is expensive and then steadily comes down in price as it’s developed. Cancer treatments just keep going up. When computers first came out they were ungodly expensive. Thirty or Forty years later they were affordable and everybody has one. Chemotherapy has been in use since the 50’s and keeps getting more expensive every year. And don’t tell me chemotherapy is more complicated than computers. It’s not. It’s based on Mustard gas from WW1. This isn’t rocket science. Even if it were it would still be cheaper because we now have cheap reusable rockets and micro satellites. So if I get cancer, my cure will most likely be a bullet to the head. I’ll be damned if I’m going to leave my family in hundreds of thousands of dollars of medical debt while they cry over me and watch me deteriorate then lose everything I’ve worked my whole life to provide for them. NO. Thanks for nothing Big Pharma.
John,
Thank you for your very reasoned explanation!
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Bob
John, if you care to dive into the subject at all, you’d see that the company that developed Provenge went bankrupt due to the high cost of producing that patient-specific custom drug. The newer the science/technology and the more custom the drug, the higher the cost of producing a safe and effective product. A cursory search shows that the three treatments cost what other products did, but in a space of a month vs months of ongoing treatment with those other drugs. The new hope lies in immunotherapy, in using the patient’s own immune system to safely fight the cancer. This technology will cost more than chemotherapy, but should provide a better life for patients until we find a way to prevent or cure each of the diverse types of cancer that afflict us.
The ‘discovery’ that cancer can be killed by one’s own immune system is not surprising. The understanding of cancer has evolved from being initially classified as a disease at the beginning of the 20th century to more recently what it really is – a failure of one’s cell reproduction and the body’s own immune system to destroy cells that have gone haywire.
Decades ago my father (who was not a doctor) understood this along with a small percentage of other people at the time that cancer was not a disease but in fact a byproduct of cell reproduction gone haywire was considered an absurd theory. The medical industry was at the same time calling such a theory garbage science.
For the last 65+ years medical ‘science’ (or should I say quackery) ‘treatment’ for cancer has and continues to use a horrific regime of radiation and a medieval chemical cocktail that all but kills a patient’s immune system (and a whole lot of other healthy cells) – the very immune system that is really needed to be operating at its full effect in order to be able to kill off the cancer cells in the first place! This ‘treatment’ has been sold to all of us as the only viable treatment for cancer and has resulted in a multi-$TRILLION$ industry that has willfully resisted every possible alternative treatment of cancer under the guise that they could be harmful to the patient!
What is truly amazing is that this all started because in 1925 the Geneva Protocol banned chemical warfare ostensibly to prevent the Germans from using it. Of course, the good ol’ USA had no intention of complying with the Geneva Protocol. The US non-compliance was discovered when the SS John Harvey, a U.S. World War II Liberty ship most well known for carrying a secret cargo of mustard gas and whose sinking by German aircraft in December 1943 at the port of Bari in south Italy caused an unintentional release of chemical weapons. The USA had to come up with some way to cover for this egregious violation of the Geneva Protocol and so went about trying to justify the cargo.
Ostensibly, a year before the bombing of the SS John Harvey two pharmacologists from the Yale School of Medicine, Louis S. Goodman and Alfred Gilman, had been recruited by the United States Department of Defense to investigate potential therapeutic applications of chemical warfare agents. (What better way to justify the continued production of such agents). Goodman and Gilman observed that mustard gas was too volatile an agent to be suitable for laboratory experiments. They exchanged a nitrogen molecule for sulfur and had a more stable compound in nitrogen mustard. A year into the start of their research a German air raid in Bari, Italy led to the exposure of more than one thousand people to the SS John Harvey’s secret cargo composed of mustard gas bombs. Dr. Stewart Francis Alexander, a Lieutenant Colonel who was an expert in chemical warfare, was subsequently deployed to investigate the aftermath. Autopsies of the victims suggested that profound lymphoid and myeloid suppression had occurred after exposure. In his report Dr. Alexander theorized that since mustard gas all but ceased the division of certain types of somatic cells whose nature was to divide fast, it could also potentially be put to use in helping to suppress the division of certain types of cancerous cells.
Using this information, Goodman and Gilman reasoned that this agent could be used to treat lymphoma, since lymphoma is a tumor of lymphoid cells.
So, the basis for the last 60+ years and the ‘standard’ and accepted cancer treatment today is based on the covering up and justification for the production and distribution of chemical weapons by the USA in violation of the Geneva Protocols.
The result of this has been the overwhelming suppression of any other possible treatment modalities for DECADES!
The irony of this is just too much….
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Bob
Thank you. I agree.
Great explanation John
How the heck are we going to stop misinformation distorting the truth. Bob, frankly you are crazy wrong and intense and harmful. I shouldn’t of read the comment section. It’s an exciting new drug working on stopping solid tumours that’s all I wanted to know but none of the comments are about that. None are about whether people think it will work in clinical trials. These are just angry people yelling because they’re scared. Cancer is scary, so believing that big pharma has the “cure” and is hiding it is easier than realising we don’t have much control over cancer. We are trying really hard and fighting really hard and Bob you won’t ever believe I word I say. Because you are scared. And sometimes it feels better to hold anger instead of vulnerability. I am so sorry for you Bob. You will never see how your sources lied to you. You will never see how you spread those lies.