A recent article published in Medical Express last week touts the impressive findings of a pre-clinical study on the experimental drug EBC-46 (pictured above). In the article, they claim that EBC-46 is able to effectively destroy tumors by destroying the blood vessels that supply it with oxygen and nutrients. It is important, however, to remember that the work they are reporting on is very preliminary and has yet to be shown to be safe or effective in humans. Many promising candidate drugs fail very early on in clinical trials because of an unforeseen side-effect or because the drug simply does not work as well in humans as in animal models.
Furthermore, EBC-46 may be a novel drug, but its target is nothing new. EBC-46 targets a protein called Protein Kinase C (PKC) that, when inhibited, prevents tumor cells from making proteins that help them live. PKC has been targeted by several compounds, with one, PMA getting a phase I clinical trial (safety and efficacy in a limited group of people with cancer). Unfortunately, PMA caused severe and life-threatening side effects and the trial was stopped.
Given the questionable history of PKC inhibitors, it has yet to be seen if EBC-46 will be safe to use in humans.
For the article upon which the press release was based see below:
Intra-Lesional Injection of the Novel PKC Activator EBC-46 Rapidly Ablates Tumors in Mouse Models
Edited by SITN Waves Editor Adam Brown.
Amygdalin, named as ‘laetrile’ and ‘vitamin B-17’ was initially supposed to be a safe drug for cancer treatment and was recognized by followers of natural medicine since it has been considered to be hydrolyzed only in cancer cells releasing toxic hydrogen cyanide (HCN), and thus destroying them. Unfortunately, current studies have shown that HCN is also released in normal cells, therefore it may not be safe for human organism. However, there have still been research works conducted on anti-cancer properties of this compound. In vitro experiments have shown induction of apoptosis by amygdalin as a result of increased expression of Bax protein and caspase-3 and reduced expression of antiapoptotic BcL-2protein. Amygdalin has also been shown to inhibit the adhesion of breast cancer cells, lung cancer cells and bladder cancer cells by decreased expression of integrin’s, reduction of catenin levels and inhibition of the Akt-mTOR pathway, which may consequently lead to inhibition of metastases of cancer cells. It has also been revealed that amygdalin in renal cancer cells increased expression of p19 protein resulting in inhibition of cell transfer from G1-phase to S-phase, and thus inhibited cell proliferation. Other studies have indicated that amygdalin inhibits NF-kβ and NLRP3 signaling pathways, and consequently has anti-inflammatory effect due to reducing the expression of proinflammatory cytokines such as pro-IL-1β. Moreover, the effect of amygdalin on TGFβ/CTGF pathway, anti-fibrous activity and expression of follistatin resulting in activation of muscle cells growth has been reported. This compound might be applicable in the treatment of various cancer cell types.
I take it daily and have done for the better part of 10 years. Its hard to know who to believe so why not hedge your bets plus i have had some family and friends beat this blight with kernels so i have a small set of data to work with. From experience money usually wins over morality, at least in our part of the world. Lets keep probing and sharing information with positive effects 🙂
I have given EBC46 to a patient (undergone 6chemos but was feeling sever pain)with just 15days before now she is not feeling the pain in her body and feeling well. I do hope it’s working.
The PMA article posted in this blog is in-correct. That’s for TPA instead.
I think PMA and TPA are the same: https://en.wikipedia.org/wiki/12-O-Tetradecanoylphorbol-13-acetate
Human trials have begun….one woman has received the injection and the tumor was gone in 24 hours. The ebc 46 came from a fruit so how dangerous can it be. When this fruit was discovered and publicized about what it can do….Big Pharma sent it s men in black to curtail the whole thing.
I hope there is a cure one day. I also wonder if we cure cancer how it will impact our current social security , nursing homes , etc. If people live to be 100 or longer how will this impact our resources?????
Hey Dave, You make a valid point. And I really don’t want to be an obstructionist with regards to what your saying, but keeping an open mind, and thinking critically and analytically is vital for furthering a common sense approach…
Hey Doc, how’s that Maserati running? I bet the view is spectacular from your palm beach home on the water… Martini happy hour on the yacht at 5?How many have died with chemo? The real question, is how many survive? What does big Pharma pay you for a single treatment? How many people will come through your doors in an overpopulated society? Thousands more where they came from… And what about those patients ? Are you numb enough after so many have died? I believe you are… people run out of tears, when so many die… like a soldier in combat, or a cop on the front line their whole life… Only difference is they don’t make millions…Your arrogance is astounding, and I would wager you voted for Hillary Clinton… conspiracy theory my ass… Blinded by marble and gold, diamonds and emeralds… your education and undying tenacity to help mankind is astonishingly absent… Your own family sees the indifference, and lack of personality you’ve acquired in your line of work… But hey, they still love all you have done for them… especially those kids in college chanting antifa and just trying to fit in… All your wealth is for nothing when you can’t be a human being anymore… And breed the same mentality… Maybe that’s not you, but you know damn well many of your colleagues are as cold as ice. And probably don’t give a shit anymore… Big Pharma is a money laundering machine… Denial is not a river in Egypt… that second martini should help ease the pain… till you get cancer. And then maybe you’ll see that chemo is bullshit… and we’re all going to die anyway. I’d rather die, than pay for that new Rolls Royce …and leave nothing for my kids…. finding a good doctor is like trying to find a good lawyer, or even a good mechanic … It ain’t easy… They all suck till you need one. And how fortunate we are when we do…. God bless the good people in our world, for they are becoming far and few between… Hell, even our researchers have more money than God, scamming taxpayer money with grants, and donations… Big money certainly is “the root of all evil.” Don’t think so? Try giving it away to those starving and dying in a world with blinders on… Isn’t it odd, that people with the least give the most? Yeah, you give more than enough… keep telling yourself that and patting yourself on the back for the humanitarian you are… saved a breast cancer patient just last week… she’s broke. But she’s alive… and her family adores you for it… and paid for a new radiology machine because the hospital budget wouldn’t buy one… (sure) even got a puppy for the little girl “Amanda” or was it Alana…in pediatrics… what a guy. God loves you for it… How about those other doctors who are persecuted for saving so many with unorthodox or not FDA approved methodology, and not making shit for money? And I’m not talking about the scammers….You call them “witch doctors” right? Or writing off a patient who just hasn’t lived a “healthy” lifestyle according to your own specifics… Hmmmm… Judge , jury, and executioner… Oncology has been good to you, and you’ve earned it. Keep telling yourself that too… you dick…It’s really not your fault, you are merely a product of your environment…and partied your ass off in college! But not quite as smart as you thought… And neither am I. Thank God… After all, we are only human… another “scapegoat.” So then what separates the good from the bad? Is there really a separation? Or do they walk hand in hand… “Take the good with the bad.” scapegoat. How are your kids doing? Direct reflection of you or can you just “blame” them for their bad choices? More like a chemical imbalance…Hmmmm… Mine actually are doing very well… And they are hard working, highly intelligent conservatives… with outstanding moral convictions and higher education… Daniel in fact has his masters in biochemistry, but decided against a PHD… works in a research lab, with many incompetent and overpaid “foreign ” workers brought over with the HB bill… and also is witness to many “infractions ” of protocol… he has been on”the carpet” more than once for not “dismissing” his findings… so my point is that all large corporations are guilty of mismanagement and greed, sadly Hospitals have negligently killed tens of thousands in our country… Even more than cancer, gun violence, and all the highway deaths combined… And yet the liberals keep taking huge money from Big Pharm… Amazing how that works… And the minions of deceit continue to brainwash the “good” people in medicine to fit their “bottom line” agendas…And how defensive and concerting they are when “helping” others is “what they do.” Long hours and lousy pay, for a seemingly and often “thankless” job… Burnt out from the work and “conspiracy theories” that they know for sure, will be their demise if they listen to it… Kind of like democrats, wouldn’t you say Dave? Perhaps my next “reference” could be a good shrink Dave… maybe 900.00 an hour? That makes them a better doctor right? Divorced, and seeing another doctor themselves, because they too are only human, and have become products of their crazy ass environment… We could go on for hours with “conspiracy theories,” but really what we’ve lost in this country is good ole fashioned common sense… For me that would be “ignoring” this post and “hope” the world will just fix itself… But then that would be hypocritical when a good debate from both sides of an opinion, lined with the “facts” and the “truth” must surely be all of our redemption… Health Science Institute has many doctors who have worked in the field of medicine for a very long time… They contradict many of today’s “breakthroughs” with regards to cancer treatment… And don’t ridicule Oncologists (like I probably shouldn’t have) out of professional courtesy… In fact, they offer to work with chemo docs to help the patient, if the acting doctor and the patient agree to it… (which is absolutely the patients decision) Your chance of survival increases dramatically… Sadly, as in a recent loss. The oncologist called my choice of reference a “witch doctor,” in spite of his impeccable rate of remission and cured patients… hundreds in fact. From brain cancer to pancreatic…But because he is harassed by FDA and Big Pharm, with insurmountable legal fees, is being labeled a “conspiracy theorist” and a “witch doctor.” So who’s really the conspiracy theorist? Even the most educated and professional doctors can be and are brainwashed. And because of their “higher learning” are respected for “whatever” they say. I just want to say, that education stops, when one stops learning… just like democrats! Ha! Sorry, but it’s true… and not just for democrats, of course not… but they are revealing themselves as such…Not wanting to offend but “wake up” even the staunchest of nay sayers… I hope somebody will just want to save a life, and do it to the best of their ability… as was always their seemingly rude and underlying intention… longwinded and off point, I apologize for simply caring…
It is already being tested on humans and working as described. Amazing.
Anyone who thinks there is some huge conspiracy should really rethink and research before pushing those ideas on others. I certainly won’t deny that there may be some promising drugs that never made it to market for one reason or another, but to accuse every cancer researcher in the world of selling out to “Big Pharma” is absurd. For one thing, isn’t it odd that people tout so many natural cancer cures, things that are readily available to everyone, but yet people still get cancer? I mean don’t you think if something just magically cured cancer we would all know and already be free of it? I mean when you get a cold, you go buy NyQuil because you know it will help. How do you know? Because everyone knows and uses it. Don’t you think if someone made a cancer cure, that they would want to sell it??? I mean financially it’s a gold mine! If you have a guaranteed cure then you can cure the same person over and over each time they get sick, instead of them dying off before you have a chance to sell them drugs for another problem. Living people are the only kind drug companies make money on. They have a vested interest in keeping people alive! Having a sister who survived cancer, I can definitely say she’s worth more to them now then she would be if she had died. Now she has to take meds for the rest of her life! And what makes you think that all these people are so cruel that they would let people die rather than the alternative. These may be companies, but they ARE run by people! Don’t you think one of those many people would have felt bad enough by now if they could be saving millions of lives to have come forward. Cancer is scary, but don’t let fear twist you into such a cynical viewpoint. And the sad part is, the reason it takes so long for drugs to make it to market is because of people like you! People that read false information and present it as fact. People that will push anything that appears to be natural, without even knowing the side effects. That’s why drugs have so much testing before they can be brought to market…..Because people will push anything they think they can make money. And people like you will snap it up if it appeals to your sensibilities! Someone on here mentioned how drug companies are responsible for many deaths due to the opiate epidemic. Wanna know what’s natural? Opiates! Ever heard of the opium poppy? It’s where many of those deadly drugs come from! Natural doesn’t mean safe!!! And for the record, you can patent natural things. I know I won’t get through to many people, if any, but it’s upsetting to me when people act like they know better than those with medical degrees and training. What if someone believes you and decides to take some natural, unproven cure instead of doing normal treatment. If my sister had, she would likely be dead now. So please think carefully before you speak. You could end up being the reason someone buries a family member.
So many conspiracy theorists contributing nothing.
Oncologists are way ahead of conspirators when it comes to knowledge of promising cancer treatments. They are in the thick of it and you are not. Personal experience of a remission at a time when you take a potion is not evidence of a panacea. Popular media promotion of an apparently amazing alternative based on stories of a remarkable recovery is not evidence of a wonderful new cure. Oncologists are not living in a cloistered environment, hidden from the wonderful information to which you have access. You cannot teach them anything about the subject.
Conspiracies and collaboration are ridiculous?
Companies and government kill people for profit. Cigarettes, DuPont for cancer causing Teflon, Johnson & Johnson Talcum powder, GM ignition switches, VW’s smog. Takata airbags, etc., etc., etc. Gulf of Tonkin false flag. LBJ’s government and military hid civilian casualties for how long?! There is an entire industry built around suing drug companies for their lies and deceit that injures and kills people for goshsakes.
So just stop denying it. It is more ridiculous to NOT believe in them. I mean I know it stinks to think we live in that kind of world, but we do. Just because you worked for a drug company that happened not to issue a company wide memo or press release letting you, or us, in on what they are doing doesn’t make it less true. I listed but a mere fraction of transgressions.