Researchers from Kyoto University in Japan started a clinical trial this month to treat Parkinson’s disease with reprogrammed stem cells. This follows the successful restoration of brain cell function in monkeys using these stem cells reported last year.
Parkinson’s disease is characterized by the loss of a specific type of neuron in the brain, called dopaminergic neurons, which make the essential neurotransmitter dopamine. The reduced dopamine levels lead to motor skill decline, causing the characteristic trembling and difficulty walking. Currently, there is no cure for Parkinson’s disease. Therapies to help relieve symptoms include lifestyle changes (diet, exercise, physical therapy), taking a drug to increase dopamine levels in the brain, and deep brain stimulation surgery to electrically inactivate the brain portions responsible for motor symptoms.
However, adding neural progenitor cells, which are derived from reprogrammed stem cells, back into the patients’ brains might replace the lost neurons and cure the disease. In monkey brains, the neural progenitor cells differentiated into dopaminergic neurons and survived for up to two years. Motor symptoms associated with Parkinson’s disease also improved after treating the monkeys.
To make the replacement dopaminergic neurons, mature adult cells (usually from the skin or blood) were treated to revert back to being stem cells, called induced pluripotent stem cells (iPSCs). At this point, the iPSCs can be reprogrammed to become many types of cells. In this case, they were turned into dopaminergic neural progenitor cells, which specifically develop into dopaminergic neurons. Using iPSCs rather than stem cells from human embryos means this treatment would be potentially available in countries that ban the use of embryonic stem cells, such as Ireland, Italy, and most African and South American countries.
Patient recruitment for this trial began this month. Seven patients will be recruited, treated with neural progenitor cells via direct injection into the brain, and studied for 2 years post-injection. Because there is a chance the immune system would react adversely to the injected cells, patients will be given a common immunosuppressant drug (Tacrolimus) during cell injection. Although the procedure in this trial requires brain surgery, it will hopefully be a long-term, effective solution.
Managing Correspondent: Chelsea Weidman Burke
Press Article: Trial Launched to Treat Parkinson’s with Reprogrammed Stem Cells. The Scientist.
Japan scientists to use ‘reprogrammed’ stem cells to fight Parkinson’s. Reuters.
First-of-its-kind clinical trial will use reprogrammed adult stem cells to treat Parkinson’s. Science.
Press Release: Doctor-Driven Clinical Trial on Parkinson’s Disease Treatment Using iPS Cell Derived Dopamine Neural Progenitor Cells. Kyoto University.
Original Journal Article: Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature.
Image Credit: Pixabay
Hi .
I was diagnosed with PD a year ago. I have Neuro stiffness on the left side with left toes often pulling stiff. I also have muscle rigidity and tightness. I am very interested in the clinical trials regarding stem cell treatment for Parkinson’s.
Thank you for sharing this post and it will help other individuals to go for treatments without any doubts.
I am fond dilliard I would like stem cell for my p.d.
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I’m looking for updates on the August 2018 trial….getting close to 2 years now. Please provide a link.
Hi I need stem cell therapy
Hi i am 41 year male with pd .i will love to be cured from this disease .my body get stiff on left side. Please let me know if this can cure me.
Hi. My Name is JoAnn. I developed Parkinson’s due to neurological Lyme disease. I just turned 63 and I’m in good physical condition. I would love to take part in a stem cell clinical trial. There are so many promising treatments on the horizon. God bless.
Hi,
It seems to be a very good news,creating strong hopes.
I am 35 year old female and suffering from parkinson for the last 8years.
Do you have any idea when this mthod could be actualy used,if successful.
Thanks and best of luck to you all.
My mom is suffering with parkinson’s disease. She is 78 years old. She was diagnosed 4 years ago. All motor functions are affected now. I saved my son’s cord blood. I’m not sure if it could be used for that. She would be very interested in a clinical trial for stem cell therapy.
Any information would be helpful