Mining DNA for Disease Prediction: the polygenic risk score

by Alex Yenkinfigures by Allie Elchert Long before the completion of the Human Genome Project, scientists knew that many common diseases had a genetic component. However, there was debate about the architecture of these genetic effects: were there a few high-effect mutations or thousands of tiny effect mutations spread throughout the genome? Now, in the full swing of the genomics revolution, we can see that … Continue reading Mining DNA for Disease Prediction: the polygenic risk score

Mutation Madness: How and why SARS-CoV-2 keeps changing

by Sophia Swartzfigures by Shreya Mantri The first reports of a mysterious, pneumonia-like illness surfaced in early December 2019. Fast-forward to 2021, and the culprit—SARS-CoV-2, a virus a thousand times smaller than a speck of dust—has sickened more than 111 million people, infected all seven continents, and killed approximately 2.5 million.  The toll of COVID-19 is heart-wrenching and borders on dystopian. Our pandemic present is … Continue reading Mutation Madness: How and why SARS-CoV-2 keeps changing

The Computer Science behind DNA Sequencing

by Alex Cabral figures by Sean Wilson In 2003, with the completion of the Human Genome Project, the entire human genome was sequenced for the first time. The sequencing cost nearly $1 billion and took 13 years to complete. Today, the human genome can be sequenced for about $1000 in less than two days. Industry leaders hope to bring that cost down to just $100 within … Continue reading The Computer Science behind DNA Sequencing