In a breakthrough for synthetic biology, an international team of researchers constructed a functioning yeast genome where more than half of its chromosomes were made in a lab. Continue reading Scientists create yeast with a half-man-made genome
Scientists have developed a biodegradable ultrasound speaker that can be placed inside the brain. When activated, it makes the blood-brain barrier permeable, potentially allowing certain drugs such as brain cancer chemotherapy and antidepressants to reaching their destination more easily. Continue reading Ultrasound speaker implant that can open a door to your brain
Doctors at Boston Children’s Hospital engineered a unique medicine to treat a young girl’s disease: they reverse engineered a blocker from her DNA to inhibit the gene causing the disease. Continue reading Individual Genetic Medicine Helps Treat Genetic Disease
Type II diabetes is a rising global epidemic without any current treatments. But scientists have designed an interesting chimeric protein that aims to increase insulin sensitivity in patients and thereby provide a potential cure. Continue reading Using Chimeric Proteins to Fight Type II Diabetes
Researchers from MIT have developed a novel method to locally deliver drugs and prevent immune activity around implanted biomedical devices over several months. The method is based on the formation of crystals of immunosuppressive drugs, which can be included in devices and slowly dissolve over the course of months. While this method substantially increases the length of time tested devices can function, difficulty of crystallizing certain drugs or introducing them into specific devices may prove to be a challenge in adapting this method to other systems. Even so, for many cases, this method will likely substantially reduce the difficulty of maintaining device stability for extended periods of time. Continue reading Slow and Steady Drug Delivery Keeps Biomedical Devices Kicking
Proteins are made up of linear sequences of amino acids but understanding how these amino acids fold to form a three-dimensional structure is notoriously difficult. Knowing what a protein looks like in 3D is often necessary for understanding how it functions and how it can be manipulated. For instance, understanding how proteins such as antibodies bind to viruses like the flu would enable scientists to … Continue reading Genetic tools create new opportunities for decoding protein structures
Researchers from the Yale School of Medicine have developed a system capable of sustaining certain aspects of brain function for several hours, even if the host animal has been dead for up to four hours beforehand. While this by no means suggests that complete restoration of neurological function is on the horizon, it reveals the surprising resilience of post-mortem brain tissue, introduces a promising technique that could allow scientists to study certain biological functions outside of live animals, and highlights the important ethical considerations that must be discussed before any potential complete resuscitation of neurological activity is achieved. Continue reading Pigs & Immortality: A Step Towards Reversing Death
Each cell in a living organism has an instruction manual known as the genome. These instructions are spelled out using letters, called bases, that pair with one another to form long double-stranded molecules of helical DNA. Life as we know it uses 4 bases called A, C, T, and G. Recently, scientists expanded this alphabet to include 8 bases – 4 natural and 4 artificial. … Continue reading Scientists create an expanded 8-letter DNA genetic code
Nerve agents are toxic chemicals that disrupt signals in the nervous system. They can be absorbed easily through skin contact or by breathing. Exposure to nerve agents interferes with nerve cell signaling and prevents muscles from relaxing, quickly leading to muscle paralysis and eventually death by asphyxiation or cardiac arrest. Treatment is possible but must be administered within minutes of exposure. No long-term vaccine or … Continue reading Nano-antidote provides long-term protection against nerve agents
Antibiotics, while life-saving, can also wreak havoc on healthy systems. The drugs work by attacking the protein-synthesizing center (ribosomes) in bacteria. When the ribosomes in human cells are mistaken for bacterial ribosomes, antibiotics can cause a range of side effects from nausea to kidney failure. To understand what conditions cause healthy cells to be attacked, scientists are implementing novel imagining techniques to study interactions between … Continue reading Biologists and Physicists Work Together to Image Subcellular Interactions Like Never Before