Avian Flu and Censorship: When Would Scientists Keep Their Mouths Shut?

Presented by Ann Fiegen, Kevin Bonham, and Tina Liu When a team of scientists discovered in 2011 how to make the deadly H5N1 “Avian flu” virus transmissible through air, it stirred a debate about scientific ethics and national security that has raged for months everywhere from the top levels of the National Institutes of Health to the front page of the New York Times. In … Continue reading Avian Flu and Censorship: When Would Scientists Keep Their Mouths Shut?

Transplantation Redux: Advances in Face Transplantation

— According to Max Eastman, “a smile is the universal welcome.” For individuals whose faces are severely disfigured due to trauma, burns or disease, a smile may be difficult, or even impossible, to express. Facial deformities may impair daily activities, such as eating, swallowing, breathing, and talking. Consequently, these individuals may hide from the public in an attempt to avoid curious stares from strangers. For those patients who have exhausted all conventional means of facial reconstruction, face transplantation offers the possibility of regaining muscle movement and sensory control in the face. For example, doctors hope that the surgical procedure will help patients to prevent drooling, display various emotions, and speak and eat more easily. Continue reading Transplantation Redux: Advances in Face Transplantation

Antibiotics and foodborne pathogens: are superbugs born in livestock?

— Despite our best efforts to wash our hands and keep raw meat separate from other ingredients while cooking, over 76 million Americans per year become ill from foodborne bacteria or the toxins produced by them. The bacterial culprits are typically E. coli, Salmonella, or Campylobacter jejuni. While gastrointestinal diseases are unpleasant, they can be treated with antibiotics that kill the offending bacteria. However, scientists and consumers alike worry that antibiotic-resistant “superbugs” may soon contaminate the food supply. One step the Food and Drug Administration (FDA) is taking to prevent such superbugs is to regulate the use of antibiotics in livestock. Continue reading Antibiotics and foodborne pathogens: are superbugs born in livestock?

Scaly Skin, Drippy Nose, Wheezy Breathing: Coincidence or Connection?

— Itchy, watery eyes, and a drippy nose. Constricted, swollen airways secreting thick mucus. Itchy, red, dry, cracked skin. These symptoms describe three conditions — allergies, asthma, and eczema, respectively — that are commonly found together in the same people. Yet, what causes these symptoms and why they are so closely associated with each other is still poorly understood. Continue reading Scaly Skin, Drippy Nose, Wheezy Breathing: Coincidence or Connection?

Obesity, Inflammation and Diabetes

— In 1985, the Centers for Disease Control (CDC) began tracking the prevalence of obesity in the United States. Since then, a clear trend has emerged: obesity is on the rise… If you’re wondering why the CDC is tracking obesity, it’s because those excess pounds have been linked to several significant health problems, including heart disease, stroke, and some forms of cancer. In fact, one study in 2009 estimated that the direct medical cost of obesity in the US accounted for $147 billion of total health-care spending. Of all the health problems associated with being overweight, one of the most significant and well-studied impact is the increased risk for diabetes. Continue reading Obesity, Inflammation and Diabetes

Dendritic cells – catalysts of the immune response

— In 1973, a young scientist by the name of Ralph Steinman became the first person to identify and describe an unusual immune cell called the dendritic cell. At a time when immunology was dominated by research on cell types known as B cells and T cells, most scientists initially considered these comparatively rare, strikingly branched cells discovered by Steinman to be nothing more than a curious oddity. Steinman and his colleagues fought an uphill battle advocating the importance of these cells in controlling the immune response, and it took almost a decade for their ideas to gain significant traction in the scientific community. Despite this initial struggle, Steinman’s ideas eventually revolutionized immunology and the greater medical field to such a degree that this year he was awarded the Noble Prize in Medicine – albeit, tragically, three days after he passed away from pancreatic cancer. Continue reading Dendritic cells – catalysts of the immune response

The man who was cured of HIV

— You may have recently heard of the first person to be cured of human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). Timothy Ray Brown was HIV-positive and also had acute myeloid leukemia, a cancer that affects white blood cells. To treat the leukemia, doctors first used radiation to kill virtually all of his white blood cells – a dangerous procedure since it is these cells that make up the immune system and protect us from disease-causing viruses and bacteria. A bone marrow transplant was then performed to give Brown the stem cells necessary to develop new white blood cells and eventually regain a healthy immune system. Doctors used this bone marrow transplant not only to treat Brown’s leukemia but to also tackle his HIV infection. HIV can infect some of the white blood cells that grow out of bone marrow. When choosing a bone marrow donor for Brown, doctors selected an individual who had a rare genetic mutation that prevents most strains of HIV from infecting their white blood cells. After receiving a successful transplant from this donor, Brown now has a new immune system full of HIV-resistant cells. Since his transplant he has not needed any anti-retrovirals, the medications used to treat HIV/AIDS, and still no HIV can be detected in his blood. Because Brown has been stably HIV-free for three years, doctors think that he is cured! But what does that mean for the 30 million other people infected with HIV around the world? Continue reading The man who was cured of HIV

African sleeping sickness and its mark on the human genome: an evolutionary tale

— Hidden deep in the rural villages of sub-Saharan Africa, a neglected tropical disease called African sleeping sickness kills tens of thousands of people every year. Sleeping sickness is caused by a single-celled parasite named Trypanosoma brucei, which can infect humans and other mammals (such as cattle and deer) and is transmitted from one host to another through the bite of the tsetse fly. Overlooked for decades, researchers are now trying to better understand both the unique biology of this important human parasite and how T. brucei might have directed the course of human evolution. It seems as though this microscopic organism has left a mark of its presence on the human genome, which scientists are only now beginning to uncover. Continue reading African sleeping sickness and its mark on the human genome: an evolutionary tale

Cancer Immunology: Not So Secret Anymore

— Scientists and prostate cancer patients alike cheered when the FDA approved Provenge, the first therapeutic vaccine for prostate cancer, in April 2010. A few months later, a second group of researchers published a clinical study that suggested the potent effects of ipilimumab, an antibody-based drug, in fighting advanced melanoma, a form of skin cancer. Provenge and ipilimumab are just two of several emerging cancer therapies that harness the body’s immune system in the battle against cancer. As we look forward to the discovery of more cancer immune therapies in the future, it is worthwhile to note that scientists have not always appreciated the link between the immune system and cancer cells. Continue reading Cancer Immunology: Not So Secret Anymore

HIV: Progress in Prevention

A study published this summer in the journal Science found, for the first time, significant success in preventing HIV infection using a vaginal microbicidal gel [1]. This finding is an important step in our understanding of HIV prevention and in curbing the global HIV pandemic. The goal of this article is to provide some background on HIV/AIDS, the current state of treatment/prevention, as well as … Continue reading HIV: Progress in Prevention