What it Takes to Make a Brain: Cellular diversity in cortical development

by Olubusola Olukoyafigures by Corena Loeb Our ability to take in information from the world around us, make inferences, and execute appropriate reactions is generated by our brains. The brain, which weighs about 1.5 kilograms in the average adult, takes up 20% of our body’s energy expenditure to power a network of roughly 86 billion cells. Ongoing research in the field of neuroscience utilizes various … Continue reading What it Takes to Make a Brain: Cellular diversity in cortical development

Dissecting cancer complexity across space and time

by Jackson Weirfigures by Jasmin Joseph-Chazan Why is cancer so difficult to cure? Why do available treatments only help a subset of patients? Why are some cancers more aggressive than others? These are questions that clinicians, scientists, and the public have pondered for generations. As it turns out, the answers are complicated because cancer biology is complicated. Luckily, new tools and technologies are helping us … Continue reading Dissecting cancer complexity across space and time

The Human-Tuberculosis Arms Race

by Sanjana Kulkarnifigures by Corena Loeb The bacteria Mycobacterium tuberculosis (TB) has been infecting humans for thousands of years. Today, TB, which is thought to have originated in Africa and evolved alongside human hosts, is found across the globe and causes 1-2 million deaths annually, making it the second leading infectious disease killer after COVID-19. As new COVID-19 variants keep emerging, we can observe the … Continue reading The Human-Tuberculosis Arms Race

Mapping Individual Microbes among the Multitudes 

by Sophia Swartzfigures by Jasmin Joseph-Chazan If you put all of the living things on Earth in a box–from humans to anteaters to teeny-tiny tardigrades–and then plucked one of these organisms out at random, it is very, very likely that you just found yourself a microbe. Microbes, although too small to be seen with the naked eye, are some of the most common forms of … Continue reading Mapping Individual Microbes among the Multitudes 

Mining DNA for Disease Prediction: The polygenic risk score

by Alex Yenkinfigures by Allie Elchert Long before the completion of the Human Genome Project, scientists knew that many common diseases had a genetic component. However, there was debate about the architecture of these genetic effects: were there a few high-effect mutations or thousands of tiny effect mutations spread throughout the genome? Now, in the full swing of the genomics revolution, we can see that … Continue reading Mining DNA for Disease Prediction: The polygenic risk score

Gene Regulatory Networks: From DNA to development

by Samantha Roylefigures by Allie Elchert Have you ever thought about how a single cell can grow into a living, breathing, human? The extraordinary complexity of our thinking brains, wiggling fingers and beating hearts emerges from a single celled zygote, formed from the fusion of egg and sperm. Many of us have heard of DNA, the molecule that contains the instructions for life, but have … Continue reading Gene Regulatory Networks: From DNA to development