DNA Damage and Skin Cancer: It’s Not All About the Sun

— A search for “DNA repair” in Amazon’s “beauty” category results in 71 hits that range in price from $15-$700, all claiming to prevent DNA damage or even to repair your DNA. Both scientists and the beauty industry know that as we grow older, our cells accumulate DNA damage while their ability to correctly repair it declines, leading to changes in appearance associated with aging, and the beauty industry is taking advantage of this fact. Whether you have commercially defined symptoms of aging or not, the cells in your body have to repair up to one million DNA lesions per day from both environmental and cellular sources. Continue reading DNA Damage and Skin Cancer: It’s Not All About the Sun

Broken genes: the role of DNA repair in preventing cancer

Presented by Jacob Sargent, Ben Morris, and Thomas Graham DNA serves as the blueprint for all living organisms on earth, but unlike most blueprints, DNA is constantly being damaged and repaired. Factors such as UV light from the sun and chemicals in cigarette smoke damage our DNA daily. Luckily, our cells contain intricate molecular machines that repair DNA damage. These DNA repair machines occasionally make … Continue reading Broken genes: the role of DNA repair in preventing cancer

An Anti-Cancer Drug with Male Contraceptive Properties

— A 2011 study in the United States reported that 49% of pregnancies were unintended in 2006 []. Across the globe, this type of trend has contributed directly to maternal mortality, as well as the ethical, social, and financial costs associated with abortions and deliveries to single mothers. The high rate of unplanned pregnancies, especially in teenagers, is, in part, due to the lack of contraceptive alternatives for men. Male contraceptive options are limited, at best, with the most prominent and widespread options being condom-use and vasectomies. An effective male contraceptive would undoubtedly help to reduce unplanned pregnancies. Surveys conducted around the world have indicated that, whatever the setting, at least 25% of men would consider using drug-based contraception, even if it meant affecting their own hormone levels []. Researchers at Harvard Medical School and the Dana-Farber Cancer Institute have designed a small molecule that dramatically reduces the generation of viable sperm, without affecting hormone levels, potentially providing a new way for men to combat unplanned pregnancy. Continue reading An Anti-Cancer Drug with Male Contraceptive Properties

Cancer: The Disease That’s Just as Smart as We Are

— On any given weekend from March until October, it’s a fair bet that somewhere in your state there’s an event raising money for cancer treatment, prevention and/or research.  It probably seems, at times, like someone should have found a cure by now – after all, there has been an organized and concerted effort to cure this disease for the better part of the last century.  What is it about cancer that makes a cure so elusive, despite the efforts of innumerable hard-working and intelligent people?  It turns out we have spent a significant part of the last century underestimating just how clever cancer can be, but researchers and doctors are beginning to develop a better view of this disease, and as a result, are developing better treatments which may one day make cancer as treatable as any other chronic but manageable disease. Continue reading Cancer: The Disease That’s Just as Smart as We Are

Pancreatic Cancer: How to Catch a Silent Killer

— When Steve Jobs died on October 5th of this year, global attention turned to his cause of death – pancreatic cancer. Many people had questions: Would his fate have been different if he hadn’t elected for alternative treatments in the early days of his diagnosis? If someone of his wealth couldn’t beat this disease, can anyone? What many people may not know is that the eight years Jobs lived with his cancer diagnosis were significantly longer than the typical pancreatic cancer patient can expect to survive. This fact has much, if not all to do with the particular type of pancreatic cancer that Jobs had. Continue reading Pancreatic Cancer: How to Catch a Silent Killer

Cancer Immunology: Not So Secret Anymore

— Scientists and prostate cancer patients alike cheered when the FDA approved Provenge, the first therapeutic vaccine for prostate cancer, in April 2010. A few months later, a second group of researchers published a clinical study that suggested the potent effects of ipilimumab, an antibody-based drug, in fighting advanced melanoma, a form of skin cancer. Provenge and ipilimumab are just two of several emerging cancer therapies that harness the body’s immune system in the battle against cancer. As we look forward to the discovery of more cancer immune therapies in the future, it is worthwhile to note that scientists have not always appreciated the link between the immune system and cancer cells. Continue reading Cancer Immunology: Not So Secret Anymore