chemistry_Carmen_Sivakumaren

Spectrum

These colorful fractions were obtained upon purifying a synthetic small-molecule through flash column chromatography. Though most of these were impurities (bright colors in organic chemistry is usually not a great sign), it served as a reminder to appreciate the beauty in the mundane and seemingly unimportant. Contributed by Carmen Sivakumaren, a graduate student in the Biological and Biomedical Sciences Program at Harvard Medical School.   Continue reading Spectrum

Pseudomonads II

Pseudomonads II

The adaptation of the opportunistic human pathogen Pseudomonas aeruginosa often produces phenotypic diversity. Here, mutants isolated from a genetic screen show notable differences in phenotype: the production of pigments, size, shape, and texture. The blue-green pigmentation seen in some mutants results from the production of pyocyanin, an excreted toxin that kills other microbes and mammalian cells. Whereas, the brown pigmentation is caused by the exocellular pigment, pyomelanin, which … Continue reading Pseudomonads II

Pseudomonads I

Pseudomonads I

The adaptation of the opportunistic human pathogen Pseudomonas aeruginosa often produces phenotypic diversity. Here, mutants isolated from a genetic screen show notable differences in phenotype: the production of pigments, size, shape, and texture. The blue-green pigmentation seen in some mutants results from the production of pyocyanin, an excreted toxin that kills other microbes and mammalian cells. Whereas, the brown pigmentation is caused by the exocellular pigment, pyomelanin, which … Continue reading Pseudomonads I

striking image

Neuronal Diversity of the Axolotl Brain

What you’re seeing is the brain of an axolotl, an organism known for its ability to regenerate many organs including the limb, heart, and spinal cord. The different colors (blue, green, red) represent some of the neuronal cell types present within the brain. Incredibly, when this region of the brain is injured, the brain regenerates with fidelity, and all of these cell types are remade. … Continue reading Neuronal Diversity of the Axolotl Brain

bright

Masquerade

Gene therapy is an approach to treating genetic diseases by re-introducing a functional copy of a gene into cells to replace the mutated, disease-causing gene. To get these genes into the cells, scientists create a vector by packaging the DNA encoding the correct gene into the outer shell–called the capsid–of a virus. A vector retains the ability of the virus to enter human cells and … Continue reading Masquerade

019. ARTERIOLE WALL - ZOOM THROUGH 3.0mb

The Blood Flow Border Patrol

The intricate network of blood microcirculation in the human body is a closed and complex one. The hierarchy of blood flow in the human body takes blood from the heart to deep organs systems, through arteries that branch out into smaller arterioles and later into microscopic capillaries. Presented here is a pseudo colored montage of images taken and combined from different magnifications that represent a … Continue reading The Blood Flow Border Patrol

fish

Zebrabow

Zebrabow embryos express random combinations of red, green, and blue fluorescent proteins, revealing a spectrum of unique hues. These same hues can be used to ‘barcode’ individual stem cells to track their birth and contribution to tissues as the embryo grows–all cells of the same hue were produced from one stem cell’s divisions. The Zebrabow system allows for long-term tissue lineage analysis, because the fluorescent proteins will … Continue reading Zebrabow