Advances in fast sequencing have pushed RNA as information carrier into the limelight of molecular biology. Now, Zhaoming Su and colleagues add high-resolution structure into the mix. Continue reading The (Very) Little Molecule that could: an HD Image Opens a New Chapter in RNA Science
by Sophia Swartzfigures by Shreya Mantri The first reports of a mysterious, pneumonia-like illness surfaced in early December 2019. Fast-forward to 2021, and the culprit—SARS-CoV-2, a virus a thousand times smaller than a speck of dust—has sickened more than 111 million people, infected all seven continents, and killed approximately 2.5 million. The toll of COVID-19 is heart-wrenching and borders on dystopian. Our pandemic present is … Continue reading Mutation Madness: How and why SARS-CoV-2 keeps changing
New data-driven RNA simulations allow scientists to observe twisting and folding in real time. Continue reading RNA Simulations Show Its Unique Ability to Move and Fold
Breakthrough research published in Nucleic Acids Research suggests SARS-CoV-2-related RNA may serve as potential drug targets for COVID-19. Continue reading Preliminary Studies Point toward New COVID-19 Drug Targets
by Apurva Govande figures by Tal Scully COVID-19, the disease caused by the newly discovered virus SARS-CoV-2, is a national emergency. We need a vaccine to prevent severe outcomes of disease, to successfully combat future outbreaks of this virus, and to ensure that businesses and schools can safely reopen. Until one is available, healthcare professionals can mitigate symptoms while deploying existing drugs that may show … Continue reading COVID-19: from treatment to prevention
Spanish translation available here. Continue reading Coronaviruses 101
CRISPR is a highly effective immune system that defends bacteria from viruses. It was recently shown that some viruses have evolved counter-defenses that protect their DNA with a nucleus-like structure. Continue reading Some viruses can defeat CRISPR with nucleus-like compartments
CRISPR 2.0 is causing quite the ruckus in the scientific community. Why? Imagine that you had written a note in permanent marker, but later decided you wanted to change a single word. Without the ability to erase, your options would be limited, and further changes might make the note illegible. New CRISPR technologies, or “base editors,” behave as molecular erasers. These molecular erasers enable you to very precisely … Continue reading CRISPR 2.0: Genome engineering made easy as A-B-C
by Amir Bitran figures by Daniel Utter Proteins, the molecules that sustain all life, are similar to cars and other machines in an important way: they require a specific, well-defined structure to function. Obviously, a random pile of car parts cannot be driven. And similarly, a protein that is not assembled correctly cannot perform crucial tasks like producing energy, supporting cell structure, and generating electric signals. In … Continue reading The Hidden Genetic Code