Arrival of Gene-Edited Babies: What lies ahead?

by Valentina Lagomarsino figures by Sean Wilson Nearly four months ago, Chinese researcher He Jiankui announced that he had edited the genes of twin babies with CRISPR. CRISPR, also known as CRISPR/Cas9, can be thought of as “genetic scissors” that can be programmed to edit DNA in any cell. Last year, scientists used CRISPR to cure dogs of Duchenne muscular dystrophy. This was a huge step forward for … Continue reading Arrival of Gene-Edited Babies: What lies ahead?

Genetic editing of human embryos in the United States ignites debate

In December 2018, a Chinese researcher, He Jiankui, shocked the world when he revealed the birth of the world’s first genetically edited babies. While it is clear that Jiankui egregiously violated university regulations and ethical standards, his announcement has since ignited a heated international dialogue about the permissibility of human embryonic gene editing. Currently, there are scientists in the United States working in university laboratories, … Continue reading Genetic editing of human embryos in the United States ignites debate

Edit Thyself: Biohacking in the age of CRISPR

by Patrick Griffin figures by Olivia Foster Wincing slightly, Josiah Zayner depressed the plunger of the syringe in his right hand. “This will modify my genes to give me bigger muscles,” he told the crowd—attendees of a biotechnology conference in San Francisco last October. They nervously laughed and then applauded, having witnessed the first instance of someone trying to edit their own genome using a … Continue reading Edit Thyself: Biohacking in the age of CRISPR

A major obstacle to CRISPR/Cas9 – preexisting immunity

The discovery of CRISPR/Cas9 is one of the biggest scientific breakthroughs in recent memory. This technology, first discovered in microbes, enables the cleaving of DNA in order to remove or replace existing genes. For a crash course into the history of CRISPR/Cas9 discovery and development with primary sources please refer to the footnote*. This technology will enable us cure many genetic diseases. Work is currently … Continue reading A major obstacle to CRISPR/Cas9 – preexisting immunity

First Human Trial of Gene Editing Technique CRISPR Approved

The first clinical trial using the gene editing technique CRISPR was given the go-ahead by panel from the US National Institutes of Health (NIH). The trial is aimed at determining if the technique is safe for use on human subjects. As there is much we have yet to learn about genes and their expression, it is a valid concern that modifying DNA in humans could … Continue reading First Human Trial of Gene Editing Technique CRISPR Approved