COVID-19 has now forced most of us into our homes for weeks. A recent study highlighted the importance of staying at home in these crucial times, even if you’re feeling well: people with mild, limited or even no symptoms at all were estimated to have caused the majority of severe COVID-19 infections and the wide geographic spread of COVID-19. Continue reading Computational models show why staying home really is the best idea
by Ziqi Chen figures by Rebecca Senft We live in a universe of viruses. It is estimated that there are billions of types of viruses on earth, and ~320,000 types that infect mammals alone. Many viral species exist in our surrounding environment. As we live, breathe, eat, talk, and go about our daily activities, the number of viruses that we come into contact with is virtually … Continue reading COVID-19 and Emerging Viral Diseases: the journey from animals to humans
CRISPR is a highly effective immune system that defends bacteria from viruses. It was recently shown that some viruses have evolved counter-defenses that protect their DNA with a nucleus-like structure. Continue reading Some viruses can defeat CRISPR with nucleus-like compartments
Doctors at Boston Children’s Hospital engineered a unique medicine to treat a young girl’s disease: they reverse engineered a blocker from her DNA to inhibit the gene causing the disease. Continue reading Individual Genetic Medicine Helps Treat Genetic Disease
by Layla Siraj figures by Rebecca Senft Imagine if you could tell, through some combination of your environment and your genetics, what illnesses you might develop. This could give you the ability to either prevent these illnesses before they even happen or catch and treat the illnesses early enough to prevent long-lasting effects. This reality is one step closer with the release of the UK … Continue reading From Genes to Disease: the release of the UK Biobank
by Tess Whitwam figures by Daniel Utter Imagine for a moment that you’re at a concert, standing close to a large loudspeaker—you can feel the vibrations from the loud music coursing through your body. Then, your friend behind you taps your shoulder, so you turn around, just as someone walks by and steps on your foot, causing you to jump back in pain. All the while, … Continue reading Force for a Cure: How sensing pressure could protect you against malaria
by Alex Cabral figures by Sean Wilson In 2003, with the completion of the Human Genome Project, the entire human genome was sequenced for the first time. The sequencing cost nearly $1 billion and took 13 years to complete. Today, the human genome can be sequenced for about $1000 in less than two days. Industry leaders hope to bring that cost down to just $100 within … Continue reading The Computer Science behind DNA Sequencing
by Rebecca Fine figures by Elayne Fivenson The Human Genome Project, one of the most ambitious scientific projects ever undertaken, achieved a monumental goal: sequencing the entire human genome. Since its completion in 2003, this project has laid the groundwork for thousands of scientific studies associating genes with human diseases. DNA and the genome: a primer First, let’s talk a little bit about terminology. DNA is … Continue reading Lessons from the Human Genome Project
by Lara Roach figures by Rebecca Senft In Greek, macrophage means “big eater,” and that is exactly their job. Like a growing teenager or athlete after a big game, macrophages are activated immune cells whose primary focus is to “eat.” But instead of, say, a plate of pasta, macrophages take in and digest pathogenic microbes, unhealthy molecules, and even other cells in the body when they … Continue reading The Big Eater: How the immune system alters the pancreas during obesity
by Julian Segert figures by Aparna Nathan In Mountain View, California, near the headquarters of Facebook and Google, lies 23andMe, a company that set out to make genetic testing approachable and affordable for the general public. The company started with the goal of providing risk assessments for genetic diseases, but has recently gained more popularity by offering insights into geographical ancestry. 23andMe is unique among … Continue reading Understanding Ownership and Privacy of Genetic Data