Over 300 million people worldwide suffer from depression. Despite the fact that depression is the leading cause of disability in the world, its biological causes have remained unclear. Recently, several studies have suggested a link between the gut microbiome and mood disorders like depression. The microbiome is an enormously diverse population of bacteria that lives in the intestine, which can affect the host’s digestive, immune, and central nervous systems. Researchers at the Pasteur Institute set out to determine exactly what that link between the microbiome and mood disorders might be.
To accomplish this, the researchers studied mice with depression caused by chronic stress. They found that when they isolated microbes from the feces of depressed mice and transferred them to healthy mice, the bacteria alone could induce depressive behaviors in the recipients. Then, the researchers analyzed differences in the metabolites found in these mice. They discovered that the depressed mice had lower levels of some metabolites in the blood and in the brain when compared to healthy mice. Specifically, there was a reduction in metabolites called endogenous cannibinoids (eCB), which are normally involved in communicating information between the body and the brain.
Importantly, the researchers showed that they could also reverse depressive behaviors in the mice. They were able to accomplish this in three different ways: by increasing eCB signaling with a drug, feeding the mice a diet high in eCB precursors, or by giving the mice a specific probiotic bacteria. As a result, this study not only helps clarify the link between diet, the gut microbiome, and mood disorders, but also suggests that microbiome-targeted treatments could be used as therapies for mood disorders like depression.
Lead Author Grégoire Chevalier is a researcher in the Microenvironment and Immunity Unit at the Pasteur Institute in Paris. Gérard Eberl is the head of this Unit and a Professor of Immunology, and Pierre-Marie Lledo is a Professor in the Perception & Memory Unit at the Pasteur Institute.
Managing Correspondent: Jaclyn Long
Original Article: Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
Press Article: Gut microbiota plays a role in brain function and mood regulation
Picture credit: Billion photos / shutterstock.com
6 thoughts on “Bacteria in the Gut can Influence Brain Function and Mood Disorders”
Great work and findings…
Nice informative article, share more interesting content like this.
For sharing this article.
Brain functions can be influenced due to bacteria, other issues, disease etc. I like what you have explained here regarding bacteria in the gut. Surely, this will help a lot of people to understand the issue. Thanks.
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Increasing evidence suggest the natural existence of bacteria in the brain. Also it is evident that the balance of bacteria in the guts affect brain function. How far does the relationship between bacteria and brain function go? Can bacteria be responsible for brain function and autonomy?
Spinal fluid was noticed to stimulate brain cells, can it be the bacteria in the fluid causing it?
I am having Gut issues and experiencing symptoms of brain bacteria. Please send information to help.
And what effect has the Bt gene in GMO corn effected bacterial microflora in human digestive tracts? We’ll never know if science doesn’t ask.