Mining DNA for Disease Prediction: The polygenic risk score

by Alex Yenkinfigures by Allie Elchert Long before the completion of the Human Genome Project, scientists knew that many common diseases had a genetic component. However, there was debate about the architecture of these genetic effects: were there a few high-effect mutations or thousands of tiny effect mutations spread throughout the genome? Now, in the full swing of the genomics revolution, we can see that … Continue reading Mining DNA for Disease Prediction: The polygenic risk score

Lessons from the Human Genome Project

by Rebecca Fine figures by Elayne Fivenson The Human Genome Project, one of the most ambitious scientific projects ever undertaken, achieved a monumental goal: sequencing the entire human genome. Since its completion in 2003, this project has laid the groundwork for thousands of scientific studies associating genes with human diseases. DNA and the genome: a primer First, let’s talk a little bit about terminology. DNA is … Continue reading Lessons from the Human Genome Project

How Science and Genetics are Reshaping the Race Debate of the 21st Century

by Vivian Chou figures by Daniel Utter Donald Trump’s election as the 45th President of the United States has been marked by the brewing storms of racial conflicts. A rise in racial incidents ensued in the immediate aftermath of Trump’s victory in November 2016. Since the beginning of 2017, over 100 bomb threats have been made against Jewish community centers and schools. Trump’s travel ban, signed in … Continue reading How Science and Genetics are Reshaping the Race Debate of the 21st Century

The Power of Big Science: Working at the cutting edge of discovery

by Tomo Lazovich figures by Alexandra Was When you picture a science experiment, you probably imagine someone wearing a white coat, hunched over a lab bench, looking through a microscope, or mixing something in a beaker. While this is not an inaccurate picture in many fields, it misses an important dimension of the modern scientific process: collaboration. In his speech at the banquet for his … Continue reading The Power of Big Science: Working at the cutting edge of discovery