A medical team at Johns Hopkins University genetically engineered a common cold virus to deposit a gene when injected into the human eye. This gene codes for a protein that binds to VEGF, another protein whose activity in old age contributes to vision loss (a disease called AMD or wet AMD). This small clinical study’s preliminary results show that just one small dose is potent enough to improve a patient’s vision loss. Continue reading Genetically engineered viruses: a medicine of the future
by Christopher Gerry figures by Mike MacArthur The last few years have seen an explosion in our capacity to study the human genetic code. In particular, a technology called CRISPR/Cas9 has been at the forefront of many of these advances, capturing the imagination of scientists and the attention of the general public. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a type of bacterial self-defense … Continue reading Is Genetic Surgery in My Future?: A conversation with Dr. John Doench about CRISPR and genome editing
Scientists at the J. Craig Venter Institute have created a fast-growing bacterial cell with a nearly-minimal number of genes necessary for survival – just 473 in total. These genes were entirely synthesized – not transplanted from a grown organism – and the creation of such a cell may allow big steps forward in gene function identification and efficient mass-production of biological molecules. Continue reading Streamlined 473-Gene Bacteria May Lead to Discoveries, Biochemical Production
by Aseda Tena figures by Shannon McArdel 122,621 people in the United States are currently eligible to receive a transplanted organ, but only about 30,000 transplants are performed each year due to a shortage of available organs. As a result, approximately 22 people die each day waiting for a transplant (1). One exciting area of research, xenotransplantation, aims to increase organ availability by using pig … Continue reading Xenotransplantation: Can pigs save human lives?