Small-Molecule Probes: Bridging the gap between understanding and curing disease

by Michael Vinyard figures by Jovana Andrejevic and Michael Vinyard Why do we have cures and medicines for some diseases but not others? Surprisingly, it is not because we cannot make the medicines; it is because we do not know enough about the diseases that need new medicines. To span the chasm between understanding the biology of a disease and successfully treating patients, we must foster … Continue reading Small-Molecule Probes: Bridging the gap between understanding and curing disease

MRSA Bacteria

Reversing Resistance: How to teach old antibiotics new tricks

It’s an all-too-common refrain nowadays, but antibiotic resistance remains one of the world’s most severe public health threats.  Bacteria have developed resistance to nearly every antibiotic drug in our arsenal, and the Healthcare Infection Society has estimated that 10 million people will die annually from antibiotic-resistant bacteria by 2050. Hoping to reverse these worrying trends, researchers from Oregon State University and Sarepta Therapeutics have developed … Continue reading Reversing Resistance: How to teach old antibiotics new tricks

Insect Zoopharmacognosy: Finding medicine where you least expect it

by Fernanda Ferreira figures by Krissy Lyon The young, scaly creature bursts from the torso of its doomed host in a mix of guts and blood and stares blinkingly at its new environment. For most people the sentence above describes a famous scene from Ridley Scott’s Alien, but for many insects it’s a daily reality. The inspiration for H.R. Giger’s nightmarish alien comes from one … Continue reading Insect Zoopharmacognosy: Finding medicine where you least expect it