Oral contraceptive pills are currently only available for women. Recently, a compound purified from a Chinese herb is found to have the ideal properties of a male contraceptive drug: efficient, reversible and non-toxic. Could a male birth control pill finally be on the horizon? Continue reading A Potential Male Oral Birth Control Pill may be on the Horizon
Breakthrough research published in Nucleic Acids Research suggests SARS-CoV-2-related RNA may serve as potential drug targets for COVID-19. Continue reading Preliminary Studies Point toward New COVID-19 Drug Targets
by Sam Zimmerman figures by Hannah Zucker If we were all mice, Alzheimer’s disease, cancer, diabetes, and most inherited disorders would be a thing of the past. We could nibble on as much cheese as we wanted without fear of heart disease and run around our favorite wheel for hours on end without knee pain because all these ailments have been cured in mice. Unfortunately, … Continue reading Why Drugs Tested in Mice Fail in Human Clinical Trials
by Melanie Basnak figures by Aparna Nathan Emily gave birth to a healthy baby boy. But, soon after the delivery, she started to feel sad and constantly overwhelmed. She could easily get irritated and was often angry. She worried that something would happen to her baby, and this obsession kept her from sleeping. Even though she had lots of support from her partner and family, she felt … Continue reading The Race Against Postpartum Depression Takes One Step Closer to the Finish Line
Approximately 12% of Americans experience migraines. For some people, the attacks are so frequent and painful that episodes can be incapacitating. Historically, doctors have tried a variety of approaches to treating the condition, including drugs that numb nerves, medications that constrict blood flow, and as well as a variety of behavioral approaches. While some patients have found relief using these methods, many are not helped … Continue reading Migraines: Can New Antibody Treatment Help Stop Treatment Resistant Migraines
by Garrett Dunlap figures by Rebecca Clements It’s no secret – pharmaceuticals are expensive for the patients who need them. One major reason for this is the cost and time needed to bring a drug to market. In our current medication pipeline, many drugs will ultimately fail during the process of development, which influences this cost. But could a better, less costly drug development process … Continue reading Organs-on-Chips: A promising future for therapeutic drugs
by Christopher Gerry The routes that lead to a career in biomedicine are as diverse as they are plentiful, but one of my colleagues has taken a particularly unorthodox path. Sonia had just graduated from law school when she learned of a “typo” in her genetic code that will almost certainly induce a fatal and untreatable brain disorder called prion disease. She and her husband, … Continue reading Risky Business: The far-reaching consequences of slashing the orphan drug tax credit
Prior to the discovery of antibiotics, bacterial infections were the leading cause of death worldwide. Now, treating infections is often a routine procedure – simply requiring a doctor’s visit and a prescribed antibiotic. However, this simple routine has become marred by the emergence of antibiotic resistance. The misuse and overuse of antibiotics is fueling the rise of resistant bacteria. In response to antibiotic exposure, bacteria have evolved … Continue reading Expanding the Antibiotic Arsenal: A New Drug of Last Resort
by Benika Pinch Fancy a pill packed with bacteria? Researchers are investigating using genetically modified bacteria, taken in pill form, to treat human disease. Informally, they are called “designer probiotics”. But, unlike probiotics (microorganisms with known health benefits), they can’t be obtained via a serving of yogurt from your local supermarket. Rather, the bacteria in question are feats of genetic engineering and are specifically designed … Continue reading Microbial Physicians: Delivering drugs with bacteria