Nanomachines are plagued by their short lifespans and the looming chaos in the environment. This group at TUM used a new tubular design made from DNA to keep the machine together, but the chaos out. Continue reading Submicroscopic Pistons Open a New Chapter for Nanomachines
Jasmin Joseph-Chazan is a second-year PhD student in the Immunology department at Harvard University. You can find her on Twitter as @chazanjasmin. Isabella Fraschilla is a Ph.D. student in the Immunology Program at Harvard Medical School. She is studying how immune cells regulate commensal gut bacteria. Cover image by Arek Socha from Pixabay. This biography is part of our “Picture a Scientist” initiative. To learn … Continue reading Gertrude Elion: Forging the path towards a cure for cancer
by Isabella Fraschilla Despite never receiving a PhD, Gertrude Elion was awarded the 1988 Nobel Prize in Medicine. She shared this prize with Sir James Black and her mentor George Hitchings for revolutionizing pharmacology by rejecting the standard trial-and-error approach for rational drug design. Their critical work in understanding drug metabolism and physiological processes resulted in the rare Nobel Prize awarded to employees of a … Continue reading Gertrude Elion: Forging the path towards a cure for cancer
Using electrical inputs and CRISPR biology, researchers have programmed bacteria to encode binary data. Continue reading Scientists Store Data in DNA of Living Bacteria
by Apurva Govande figures by Tal Scully COVID-19, the disease caused by the newly discovered virus SARS-CoV-2, is a national emergency. We need a vaccine to prevent severe outcomes of disease, to successfully combat future outbreaks of this virus, and to ensure that businesses and schools can safely reopen. Until one is available, healthcare professionals can mitigate symptoms while deploying existing drugs that may show … Continue reading COVID-19: from treatment to prevention
by Catherine Gutierrez figures by Aparna Nathan Forty-nine years ago, President Richard Nixon launched a “War on Cancer”. That war has not ended—it rages on today, with cancer right behind heart disease as the leading cause of death in the United States. Nearly 1.8 million new cases of cancer are expected in 2020 in the U.S. alone, and rising rates of cancer risk factors such … Continue reading Cancers Evolve – Tagging and Tracking Can Help Us Understand How
by Sam Zimmerman figures by Hannah Zucker If we were all mice, Alzheimer’s disease, cancer, diabetes, and most inherited disorders would be a thing of the past. We could nibble on as much cheese as we wanted without fear of heart disease and run around our favorite wheel for hours on end without knee pain because all these ailments have been cured in mice. Unfortunately, … Continue reading Why Drugs Tested in Mice Fail in Human Clinical Trials
by Sydney Sherman figures by Aparna Nathan More likely than not, you or someone you know has taken a genetic test. Whether they are curious about their ethnic roots and family tree or want to determine their risk for developing a certain disease, consumers have access to genetic testing as a simple “spit-and-send” process. We use the technology and rely on the results, but how … Continue reading What can we learn from a genetic test?
by Aparna Nathan figures by Abagail Burrus Superheroes aren’t the only ones with riveting origin stories. As humans, where did we come from? How did we populate six continents? For hundreds of years, archaeology has tried to provide the answers by digging up artifacts and piecing together their histories. However, shovels and brushes are now joining forces with test tubes and lab coats. Within the … Continue reading Digging for DNA: Ancient genomes can illuminate the past and reframe the present
CRISPR is a highly effective immune system that defends bacteria from viruses. It was recently shown that some viruses have evolved counter-defenses that protect their DNA with a nucleus-like structure. Continue reading Some viruses can defeat CRISPR with nucleus-like compartments