While you are likely familiar with the annoying experience of being a mosquito’s ‘meal of the day’, more is going on behind the scenes of that insect bite than meets the eye. Mosquitoes, which are drawn to human scent and breath, require proteins from the blood of their victims to develop their eggs and reproduce. This sounds harmless enough, but mosquitoes also excel at picking … Continue reading New Drug May Prevent Mosquitoes From Wanting to Bite You
In December 2018, a Chinese researcher, He Jiankui, shocked the world when he revealed the birth of the world’s first genetically edited babies. While it is clear that Jiankui egregiously violated university regulations and ethical standards, his announcement has since ignited a heated international dialogue about the permissibility of human embryonic gene editing. Currently, there are scientists in the United States working in university laboratories, … Continue reading Genetic editing of human embryos in the United States ignites debate
A Chinese researcher, He Jiankui, shocked the world two weeks ago when he revealed that the world’s first genetically edited babies had been born. Jiankui claimed to have edited embryos before implanting them into the mother as part of an otherwise routine in vitro fertilization (IVF) procedure. Since his bold announcement via YouTube, the scientific community at-large – both in the United States and in … Continue reading China’s Genetically Edited babies: What really happened?
In an exciting step forward, dogs with Duchenne muscular dystrophy (DMD) were treated with the CRISPR genome editor to restore production of the missing protein responsible for the disease. After more studies to prove it is safe and effective long-term, this has the potential to move into clinical trials as a DMD therapy. “[The dogs] showed obvious signs of behavioral improvement – running, jumping – … Continue reading Dogs with muscular dystrophy receive CRISPR treatment: What does this mean for humans?
by Jessalyn Ubellacker figure by Jovana Andrejevic Between September 1999 and June 2000, the first human genome was sequenced. Since then, scientists have learned not only to read the human genome, but also to manipulate it, offering unprecedented opportunities to improve human health through genetic alterations. One example of this is gene drive technology, which circumvents classical inheritance patterns to ‘drive’ the presence of particular … Continue reading Buckle Up for Gene Drives of the Future!
For as long as humans have conceived of making hybrid organisms, an ethical debate has been waged over whether or not we should. The pros and cons are vast and poignant. Each new scientific advancement towards making hybrids stokes the fire of controversy. This year, researchers presented work at a conference detailing the most recent hybrid: a sheep-human chimera. To create these chimeras, scientists used … Continue reading Scientists have created sheep that are 0.01% human
by Patrick Griffin figures by Olivia Foster Wincing slightly, Josiah Zayner depressed the plunger of the syringe in his right hand. “This will modify my genes to give me bigger muscles,” he told the crowd—attendees of a biotechnology conference in San Francisco last October. They nervously laughed and then applauded, having witnessed the first instance of someone trying to edit their own genome using a … Continue reading Edit Thyself: Biohacking in the age of CRISPR
The discovery of CRISPR/Cas9 is one of the biggest scientific breakthroughs in recent memory. This technology, first discovered in microbes, enables the cleaving of DNA in order to remove or replace existing genes. For a crash course into the history of CRISPR/Cas9 discovery and development with primary sources please refer to the footnote*. This technology will enable us cure many genetic diseases. Work is currently … Continue reading A major obstacle to CRISPR/Cas9 – preexisting immunity
Many diseases are caused by genetic mutations. Small mutations can cause certain cancers, some cases of blindness, influence heart disease, and many other pathologies. A new and powerful technology called CRISPR-Cas9 aims to correct for these genetic mutations by cutting out a piece of malfunctioning DNA, and replacing it with a piece of genetic material that functions correctly. Biologists first discovered CRISPR-Cas9 in bacteria. Through careful … Continue reading You are unique – Does your gene editing treatment need to be too?
CRISPR 2.0 is causing quite the ruckus in the scientific community. Why? Imagine that you had written a note in permanent marker, but later decided you wanted to change a single word. Without the ability to erase, your options would be limited, and further changes might make the note illegible. New CRISPR technologies, or “base editors,” behave as molecular erasers. These molecular erasers enable you to very precisely … Continue reading CRISPR 2.0: Genome engineering made easy as A-B-C