Why Drugs Tested in Mice Fail in Human Clinical Trials

by Sam Zimmerman  figures by Hannah Zucker If we were all mice, Alzheimer’s disease, cancer, diabetes, and most inherited disorders would be a thing of the past. We could nibble on as much cheese as we wanted without fear of heart disease and run around our favorite wheel for hours on end without knee pain because all these ailments have been cured in mice. Unfortunately, … Continue reading Why Drugs Tested in Mice Fail in Human Clinical Trials

What can we learn from a genetic test?

by Sydney Sherman figures by Aparna Nathan More likely than not, you or someone you know has taken a genetic test. Whether they are curious about their ethnic roots and family tree or want to determine their risk for developing a certain disease, consumers have access to genetic testing as a simple “spit-and-send” process. We use the technology and rely on the results, but how … Continue reading What can we learn from a genetic test?

Is diabetes communicable?

CIFAR Fellows’s paper questions whether diabetes, heart attacks and strokes are actually non-communicable diseases (NCDs). Microbiota (bacteria, viruses, fungi) that spread flu, HIV/AIDS, may also carry NCDs. People with NCDs have damaged microbiota, causing disease when transmitted into healthy animals. Spouses and cohabitants’ shared lifestyles and environments also lead to gut bacteria transfer.
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Digging for DNA: Ancient genomes can illuminate the past and reframe the present

by Aparna Nathan figures by Abagail Burrus Superheroes aren’t the only ones with riveting origin stories. As humans, where did we come from? How did we populate six continents? For hundreds of years, archaeology has tried to provide the answers by digging up artifacts and piecing together their histories. However, shovels and brushes are now joining forces with test tubes and lab coats. Within the … Continue reading Digging for DNA: Ancient genomes can illuminate the past and reframe the present