Pseudomonads I

Bacteria of Another Color

The adaptation of the opportunistic human pathogen Pseudomonas aeruginosa often produces phenotypic diversity. Here, mutants isolated from a genetic screen show notable differences in phenotype: the production of pigments, size, shape, and texture. The blue-green pigmentation seen in some mutants results from the production of pyocyanin, an excreted toxin that kills other microbes and mammalian cells. Whereas, the brown pigmentation is caused by the exocellular pigment, pyomelanin, which … Continue reading Bacteria of Another Color

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Neuronal Diversity of the Axolotl Brain

What you’re seeing is the brain of an axolotl, an organism known for its ability to regenerate many organs including the limb, heart, and spinal cord. The different colors (blue, green, red) represent some of the neuronal cell types present within the brain. Incredibly, when this region of the brain is injured, the brain regenerates with fidelity, and all of these cell types are remade. … Continue reading Neuronal Diversity of the Axolotl Brain

iMEMS

A new medical implant might greatly reduce the risk of chemotherapy treatment

Chemotherapy is a common and dangerous cancer treatment due to the negative effects on everything that is not a tumor cell. Researchers from Columbia University have invented a soft medical implant capable of administering drugs from inside the body. The ability to place this device close to the target area allows for a significant (90%) reduction of the drug dosage to be used. Similarly, avoiding body-wide administration of the drug can greatly reduce the damage inflicted by normal chemotherapy dosages. Continue reading A new medical implant might greatly reduce the risk of chemotherapy treatment

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Parental weight and its impact on early childhood development

According to the CDC, 70.7% of the US population is overweight or obese (BMI>30), with 37.9% being obese. Obesity related health expenses accounted for an estimated $147 billion in healthcare spending in 2008 alone. The dire health consequences for obese individuals include higher incidence of high blood pressure, type 2 diabetes and coronary heart disease to name a few on top of overall decrease in … Continue reading Parental weight and its impact on early childhood development

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The Blood Flow Border Patrol

The intricate network of blood microcirculation in the human body is a closed and complex one. The hierarchy of blood flow in the human body takes blood from the heart to deep organs systems, through arteries that branch out into smaller arterioles and later into microscopic capillaries. Presented here is a pseudo colored montage of images taken and combined from different magnifications that represent a … Continue reading The Blood Flow Border Patrol

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The Tricky Business of Targeting Cancers’ “Master Regulators”

Over the past few decades, cancer therapies have become increasingly targeted, with protein and antibody drugs targeting specific proteins with exquisite selectivity. Often, however, the utility of targeted therapies is limited; there are many different paths to outwardly similar cancers, and targeted therapies are often only effective against very specific cancer subtypes. An alternative strategy, championed by cancer researchers at Columbia University, is to target … Continue reading The Tricky Business of Targeting Cancers’ “Master Regulators”

slimemold

Slime molds are capable of passing on learned behaviors to new cell populations

A group at Toulouse University in France has found that slime molds are capable of passing on learned behaviors from population to another. After learning how to navigate around an unpleasant stimulus in order to reach its food, the slime mold was merged with a naïve slime mold and then separated. The naïve slime mold then underwent the original experiment and demonstrated the learned behaviors, despite never having been in that situation before. Continue reading Slime molds are capable of passing on learned behaviors to new cell populations