Are microglia the hero or the villain in Alzheimer’s disease?

by Gizem Terzioglufigures by MJ Park Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide, and despite years of research efforts, there is still no cure. However, recent studies have highlighted the crucial roles of microglia, the resident immune cells of our brain, in the development and progression of Alzheimer’s disease. But the question remains: do microglia defend our brain against … Continue reading Are microglia the hero or the villain in Alzheimer’s disease?

Microglia: The protectors of the brain

by Muhammet M. Ozturkfigures by Wei Wu For decades, scientists have been intrigued by how the brain controls the body. This curiosity led them to discover neurons, the brain’s messenger cells. Neurons, which receive, transmit, and process information, are arguably the most famous cells in our brain. The attention they get might suggest that the brain is only made up of neurons. However, about half … Continue reading Microglia: The protectors of the brain

Why Drugs Tested in Mice Fail in Human Clinical Trials

by Sam Zimmerman  figures by Hannah Zucker If we were all mice, Alzheimer’s disease, cancer, diabetes, and most inherited disorders would be a thing of the past. We could nibble on as much cheese as we wanted without fear of heart disease and run around our favorite wheel for hours on end without knee pain because all these ailments have been cured in mice. Unfortunately, … Continue reading Why Drugs Tested in Mice Fail in Human Clinical Trials