Results from a phase 2 clinical trial reveal that a new two-drug therapy for ALS can slow disease progression by six weeks over a six-month period. This therapy could possibly improve lifespan and quality of life, and may be effective in other neurodegenerative disorders as well. Continue reading Slowing ALS with a Two-Drug Therapy
Scientists have uncovered a new mechanism by which important components of cells can be damaged. Such a discovery could provide new insight into the biology of aging, cancer, and degeneration, as well as development of new drugs and strategies for food preservation. Continue reading A Radical New Mechanism for Cell Damage
Electrical recordings from human subjects have revealed the existence of memory-trace cells, which change their response depending on which previous experience is supposed to be recalled, providing a major insight into how the brain remembers specific events. Continue reading Learning to Remember: Memory-Trace Cells
Drugs that inhibit formation of protein clumps may help treat degenerative diseases, but determining when to administer them is challenging. Using mathematical modelling, researchers have developed a strategy to design better treatment protocols based on individual drug properties. Continue reading Mathematical Modeling to Treat Degenerative Diseases
Rather than try to get a glimpse into the brain, which is notoriously difficult, a new study shows that signs of Alzheimer’s disease may appear in the blood, which is a lot more accessible. Continue reading The future of Alzheimer’s disease detection could be as simple as a blood test
Bacteria in the human gut can modify the ingested drugs rendering them useless. Scientists discovered how the gut bacteria degrade a Parkinson’s disease medicine and found a way to stop them from stealing our drugs. Continue reading Hey, those bacteria are stealing our drugs!
As you read this article, you may not be consciously trying to memorize each sentence, but the words do need to stick around temporarily. After all, you have to remember what you just read to understand the full article. This is your working memory, sometimes called “short-term memory,” and it allows us to remember things just long enough to complete a task. Its decline is … Continue reading Need to jog your memory? A zap to the brain could help
They say you can’t teach an old dog new tricks – but maybe you can have an old brain grow new neurons. New research published in Nature Medicine has shed some light onto the debated topic of whether adult brains can create new neurons in the hippocampus, the region of the brain that is important in short- and long-term memory consolidation. As you might expect, … Continue reading Old Brain, New Neurons?
Alzheimer’s disease is the leading cause of dementia. It progressively worsens multiple aspects of health over time, from short-term memory loss to behavioral changes to loss of bodily functions. The actual cause of Alzheimer’s is currently unknown. One widely-accepted hypothesis proposes that Alzheimer’s is caused by the accumulation of misfolded proteins in the brain. Unfortunately, many drugs targeting misfolded proteins perform poorly in clinical trials, … Continue reading Oral bacteria may be responsible for Alzheimer’s disease
In 2018, approximately 5.7 million Americans are living with Alzheimer’s dementia, a number that is expected to double within the next 30 years. Alzheimer’s disease causes memory loss, mood changes, and eventually difficulty speaking, swallowing, and walking. Currently, no medication exists that can slow or stop the progression of Alzheimer’s disease and no new treatments have been approved by the FDA in more than 15 … Continue reading Hope for Alzheimer’s patients? The first positive clinical trial results in years