A few years ago, the ice bucket challenge took the internet by storm, bringing attention to ALS, or Amyotrophic Lateral Sclerosis. ALS is a neurological disease and its causes are mostly unknown. One possible cause of ALS could be our gut microbiome. The gut microbiome is a huge source of important small molecule chemicals called metabolites (such as taurine, tryptamine and butyrate) in our body and has been implicated in many diseases, such as Alzheimer’s disease and autism.

A group of scientists investigated whether the microbiome plays a role in ALS. Using an ALS mouse model, they first treated ALS-mice with antibiotics to deplete the gut microbiome. They noticed that antibiotic treatment exacerbated ALS symptoms. Then, they zoomed in on the strains of bacteria that were found to be affected the most after antibiotic treatment and studied their individual effect. They determined that Ruminococcus torques & Parabacteroides distasonis worsened ALS symptoms in mice.

Encouragingly, these scientists uncovered that Akkermansia muciniphila (AM) significantly ameliorated ALS symptoms in mice, and also prolonged their lifespan. In order to further understand the mechanism behind this, they looked at the differences in metabolites inside the body of ALS-mice and AM-supplemented ALS-mice. They found a significant increase in nicotinamide (NAM, a form of vitamin B3 and a common dietary supplement) in AM-supplemented mice. Treating ALS-mice with NAM improved ALS symptoms, but did not prolong their lifespan, suggesting that there are more undiscovered mechanisms.

Lastly, the scientists analyzed blood and faeces samples from human ALS patients. ALS patients were found to have a decrease in genes involved in NAM metabolism and a decrease in NAM concentration in blood, verifying the clinical significance of their study. These results are very preliminary, but they highlight the potential of modulating the gut microbiome to treat ALS. This study examined one of the many mechanisms by which our gut microbiome can affect our body, and many more unexplored pathways remain to be studied.

Managing Correspondent: Wei Li

Original Article: Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature.

Media coverage: Commensal bacterium reduces ALS symptoms in mice. The Scientist.

Boosting a gut bacterium helps mice fight an ALS-like disease. Science News.

Image Credit: Pixabay

4 thoughts on “The Next Ice Bucket Challenge: Modulating Your Gut Microbiome to Treat ALS

  1. Motor Neurone Disease NSW!! My stepdad was diagnosed with MND ALS in the summer of 2013; His initial symptoms were quite noticeable. He first experienced weakness in his right arm and his speech and swallowing abilities were profoundly affected. We all did our best to seek help for this disease no medications they prescribe worked, we were all scared we might lose him due to his condition, as he had been his brother’s caregiver a few years earlier for the same disease before he passed. The doctor recommends natural treatment from Multivitamin herbal cure for his ALS we have no choice but to give a try on natural organic treatment, this herbal cure has effectively reversed my father’s condition, losing his balance which led to stumbling and falling stopped after completing the herbal supplement which includes his weakness in his right arm and his speech. Home remedies from www. multivitamincare. org is the best although their service is a little bit expensive it is worth it, they save lives.

  2. I don’t understand these results. All of the recent studies show obesity and type 2 diabetes as reducing risk for ALS. But Akkermansia is thought to help ameliorate obesity and type 2 diabetes. Nicotinamde gives people a lot of energy so it makes sense that it would be linked with increased metabolism. But it seems many ALS patients have a problem with increased metabolism. I just wonder how if it is really working the way they are guessing and i’m given you 100% that this healthmedlabclinic.com have cure for ALS, they cure my unce who was 78 years of age, please try to contact them healthmedlab@gmail.com

  3. Am so happy my Daughter got cured of ALS which almost make her disable and taken her life, please help me in thanking this clinic for their good work by healing ALS patient, they are so great and useful to the state, they are not here to cheat on sick people but ready to help the sick, my Daughter get herself back to feet after 4 Months of medication, here is their email if you need their help healthmedlab@gmail.com

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